Positron emission tomography-positive thyroid nodules: rate of malignancy and histological features.
ANZ J Surg
; 86(6): 487-91, 2016 Jun.
Article
em En
| MEDLINE
| ID: mdl-25169781
ABSTRACT
BACKGROUND:
Thyroid nodules may be incidentally detected on (18) F-FDG-positron emission tomography (PET) scans. Previous reports suggest a high incidence of malignancy in FDG-avid nodules. The aims of this study were to examine the incidence of malignancy in a large cohort and to report on the histological features. The findings suggest that poor prognostic histologic features are often associated with FDG-avid thyroid nodules and this may have clinical implications.METHODS:
A retrospective review of prospectively collected data was conducted. A database containing all patients who underwent PET scanning at a single tertiary referral centre from January 2006 to January 2013 was searched to identify those with incidental PET-positive thyroid nodules. Patients with known preexisting thyroid disease were excluded from analysis. The demographics, fine-needle aspiration (FNA) biopsy result and operative histopathology were analysed.RESULTS:
A total of 27 851 FDG-PET scans were performed of which 221 found incidental PET-positive thyroid nodules (incidence 0.8%). Fifty-three patients went on to have further investigation and 21 of these were found to have malignant disease (incidence 39.6%). Histopathological examination of 12 malignant nodules revealed an expected rate of poor prognostic features, including poorly differentiated subtype (8.3%), lymphovascular invasion (16.7%), perineural invasion (8.3%) and extrathyroid extension (33.3%).CONCLUSION:
Our data indicate that PET-positive thyroid nodules are associated with a high incidence of malignancy. This finding provides strong support for further investigation including FNA biopsy in all surgically suitable patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
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Neoplasias da Glândula Tireoide
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Nódulo da Glândula Tireoide
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Tomografia por Emissão de Pósitrons
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
ANZ J Surg
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Austrália