Transcriptional characterization of the T cell population within the salmonid interbranchial lymphoid tissue.
J Immunol
; 193(7): 3463-9, 2014 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-25172486
ABSTRACT
Previously, our group has shown that the interbranchial lymphoid tissue (ILT) is a distinct structure largely consisting of T cells embedded in a meshwork of epithelial cells, with no direct resemblance to previously described lymphoid tissues. In this study, we aim to focus on the T cell population and the possibility of the ILT being a thymus analog. By characterizing structural responsiveness to Ag challenge, the presence of recombination activating genes, and different T cell-related transcripts, we attempt to further approach the immunological function of the ILT in salmonid gills. In addition to eight healthy individuals, a group of eight infectious salmon anemia virus-challenged fish were included to observe T cell responses related to infection. The results showed reduced size of ILT in the infected group, no expression of RAG-1 and -2, and a high degree of T cell diversity within the ILT. Taking into account that the ILT can be regarded as a strategically located T cell reservoir and possibly an evolutionary forerunner of mammalian MALTs right at the border to the external environment, the alteration in transcription observed may likely represent a shift in the T cell population to optimize local gill defense mechanisms.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
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Linfócitos T
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Regulação da Expressão Gênica
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Salmo salar
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Brânquias
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Tecido Linfoide
Limite:
Animals
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2014
Tipo de documento:
Article