Maternal multivitamin supplementation reduces the risk of diarrhoea among HIV-exposed children through age 5 years.
Int Health
; 6(4): 298-305, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25173342
ABSTRACT
BACKGROUND:
The aim of this study was to determine whether maternal vitamin supplementation affects long-term mortality and morbidity of children born to HIV-infected mothers.METHODS:
In total, 1078 HIV-infected pregnant woman were enrolled in a double-blind, 2×2 factorial, randomised, placebo-controlled trial in Tanzania. Data were collected for 874 children at monthly clinic visits through a median age of 51 months.RESULTS:
Maternal receipt of multivitamins (HR=0.93; 95% CI 0.70-1.22) or vitamin A (HR=1.00; 95% CI 0.76-1.32) did not affect all-cause child mortality through age 5 years. Among HIV-negative children, maternal multivitamin supplementation was associated with a lower mortality rate up to 5 years (HR=0.60; 95% CI 0.38-0.95), primarily in children <2 years of age. Maternal vitamin A supplementation did not significantly affect child mortality up to 5 years (HR=0.76; 95% CI 0.48-1.20). Children born to mothers who received multivitamins had a lower risk of all types of diarrhoea (RR=0.86; 95% CI 0.75-0.98) through 5 years of age. The reduced risk of watery diarrhoea persisted in children from 2-5 years of age (RR=0.71; 95% CI 0.54-0.95).CONCLUSIONS:
Maternal vitamin supplementation during pregnancy and lactation may be associated with long-lasting affects in HIV-exposed children [ClinicalTrials.gov Identifier NCT00197743].Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitaminas
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Infecções por HIV
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Mortalidade Infantil
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Suplementos Nutricionais
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Fenômenos Fisiológicos da Nutrição Materna
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Mortalidade da Criança
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Diarreia
Tipo de estudo:
Clinical_trials
/
Etiology_studies
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Incidence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
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Pregnancy
País/Região como assunto:
Africa
Idioma:
En
Revista:
Int Health
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos