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DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
Bharti, Sanjay Kumar; Sommers, Joshua A; Zhou, Jun; Kaplan, Daniel L; Spelbrink, Johannes N; Mergny, Jean-Louis; Brosh, Robert M.
Afiliação
  • Bharti SK; From the Laboratory of Molecular Gerontology, NIA, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland 21224.
  • Sommers JA; From the Laboratory of Molecular Gerontology, NIA, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland 21224.
  • Zhou J; the ARNA Laboratory, University of Bordeaux, F-33000 Bordeaux, France, INSERM U869, Institut Européen de Chimie et Biologie (IECB), F-33600 Pessac, France.
  • Kaplan DL; the Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida 32312.
  • Spelbrink JN; the FinMIT Centre of Excellence, BioMediTech and Tampere University Hospital, Pirkanmaa Hospital District, University of Tampere, FI-33014 Tampere, Finland, and the Department of Pediatrics, Nijmegan Centre for Mitochondrial Disorders, Radboud University Medical Centre, Geert Grooteplein 10, P. O. B
  • Mergny JL; the ARNA Laboratory, University of Bordeaux, F-33000 Bordeaux, France, INSERM U869, Institut Européen de Chimie et Biologie (IECB), F-33600 Pessac, France.
  • Brosh RM; From the Laboratory of Molecular Gerontology, NIA, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland 21224, broshr@mail.nih.gov.
J Biol Chem ; 289(43): 29975-93, 2014 Oct 24.
Article em En | MEDLINE | ID: mdl-25193669
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Doença / Deleção de Sequência / DNA Helicases / Proteínas Mitocondriais / Replicação do DNA / Quadruplex G / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Doença / Deleção de Sequência / DNA Helicases / Proteínas Mitocondriais / Replicação do DNA / Quadruplex G / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article