Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers.
J Am Chem Soc
; 136(39): 13709-14, 2014 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-25198059
ABSTRACT
The delivery of exogenous agents can enable noninvasive disease monitoring, but existing low-dose approaches require complex infrastructure. In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state. We establish a customized single molecule detection assay that enables urinary discrimination of thromboembolic disease in mice using doses of the nanoparticulate diagnostic agents that fall under regulatory guidelines for "microdosing."
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trombina
/
Nanopartículas
/
Tromboembolia Venosa
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Animals
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos