Gender effects on treatment response to interferon-beta in multiple sclerosis.
Acta Neurol Scand
; 130(6): 374-9, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25208455
ABSTRACT
BACKGROUND:
Gender appears to play a role in incidence and disease course of multiple sclerosis (MS).OBJECTIVE:
The objective was to determine whether male and female patients with MS respond differently to interferon-beta treatment in terms of reduction in relapse rates.METHODS:
We included all 2033 patients with relapsing-remitting MS who started treatment with interferon-beta from 1996 to 2003, identified from the Danish Multiple Sclerosis Treatment Register. We defined neutralizing antibody (NAb)-positive and NAb-negative periods in the single patient by the results of the NAb tests. Patients served as their own controls, and relapse rates were compared between NAb-negative and NAb-positive periods.RESULTS:
NAbs significantly abrogated the interferon-beta treatment efficacy in both genders. The all-over womenmen relapse rate ratio irrespective of NAb status was 1.47 (95%CI; 1.28-1.68). In a generalized linear Poisson models analysis with relapse counts as response variable, the main effects NAbs, sex, age at treatment start and number of relapses in 2 years before treatment start were strongly significant, but the effect of NAbs on relapse rates did not differ significantly between men and women.CONCLUSION:
As NAbs influenced the on-treatment relapse rates strongly in both sexes but without statistical significant difference, there is no indication of different effects of interferon-beta in men or women.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Caracteres Sexuais
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Interferon beta
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Esclerose Múltipla Recidivante-Remitente
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Anticorpos Neutralizantes
/
Fatores Imunológicos
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Acta Neurol Scand
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Dinamarca