Estimated risk of radiation-induced cancer from paediatric chest CT: two-year cohort study.
Pediatr Radiol
; 45(3): 329-36, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25274469
ABSTRACT
BACKGROUND:
The increasing absolute number of paediatric CT scans raises concern about the safety and efficacy and the effects of consecutive diagnostic ionising radiation.OBJECTIVE:
To demonstrate a method to evaluate the lifetime attributable risk of cancer incidence/mortality due to a single low-dose helical chest CT in a two-year patient cohort. MATERIALS ANDMETHODS:
A two-year cohort of 522 paediatric helical chest CT scans acquired using a dedicated low-dose protocol were analysed retrospectively. Patient-specific estimations of radiation doses were modelled using three different mathematical phantoms. Per-organ attributable cancer risk was then estimated using epidemiological models. Additional comparison was provided for naturally occurring risks.RESULTS:
Total lifetime attributable risk of cancer incidence remains low for all age and sex categories, being highest in female neonates (0.34%). Summation of all cancer sites analysed raised the relative lifetime attributable risk of organ cancer incidence up to 3.6% in female neonates and 2.1% in male neonates.CONCLUSION:
Using dedicated scan protocols, total lifetime attributable risk of cancer incidence and mortality for chest CT is estimated low for paediatric chest CT, being highest for female neonates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Radiografia Torácica
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Tomografia Computadorizada Espiral
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Neoplasias Induzidas por Radiação
Tipo de estudo:
Etiology_studies
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Guideline
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Incidence_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Revista:
Pediatr Radiol
Ano de publicação:
2015
Tipo de documento:
Article