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From pharmacogenetics to pharmacometabolomics: SAM modulates TPMT activity.
Karas-Kuzelicki, Natasa; Smid, Alenka; Tamm, Riin; Metspalu, Andres; Mlinaric-Rascan, Irena.
Afiliação
  • Karas-Kuzelicki N; Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.
Pharmacogenomics ; 15(11): 1437-49, 2014 Aug.
Article em En | MEDLINE | ID: mdl-25303295
AIM: In the present study, the influence of SAM on TPMT activity in vivo on human subjects was investigated. SUBJECTS & METHODS: A total of 1017 donors from the Estonian Genome Center of the University of Tartu (Estonia) were genotyped for common TPMT variants, evaluated for TPMT activity, SAM levels, a set of 19 biochemical and ten hematological parameters and demographic data. RESULTS: After adjustment in multiple regression models and correction for multiple testing, from the 43 factors that were tested, only TPMT genotype (p = 1 × 10(-13)) and SAM levels (p = 1 × 10(-13)) were found to significantly influence TPMT activity. The influence of SAM on TPMT activity was more pronounced in TPMT-heterozygous than wild-type individuals. CONCLUSION: SAM represents a potential pharmacometabolomic marker and therapeutic agent in TPMT-heterozygous subjects.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: S-Adenosilmetionina / Variação Genética / Metiltransferases Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Pharmacogenomics Assunto da revista: FARMACOLOGIA / GENETICA MEDICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Eslovênia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: S-Adenosilmetionina / Variação Genética / Metiltransferases Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Pharmacogenomics Assunto da revista: FARMACOLOGIA / GENETICA MEDICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Eslovênia