Experimental and computational evidence for the mechanism of intradiol catechol dioxygenation by non-heme iron(III) complexes.
Chemistry
; 20(48): 15686-91, 2014 Nov 24.
Article
em En
| MEDLINE
| ID: mdl-25322920
ABSTRACT
Catechol intradiol dioxygenation is a unique reaction catalyzed by iron-dependent enzymes and non-heme iron(III) complexes. The mechanism by which these systems activate dioxygen in this important metabolic process remains controversial. Using a combination of kinetic measurements and computational modelling of multiple iron(III) catecholato complexes, we have elucidated the catechol cleavage mechanism and show that oxygen binds the iron center by partial dissociation of the substrate from the iron complex. The iron(III) superoxide complex that is formed subsequently attacks the carbon atom of the substrate by a rate-determining C-O bond formation step.
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
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Compostos Férricos
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article