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The effects of eupatilin (stillen®) on motility of human lower gastrointestinal tracts.
Ryoo, Seung-Bum; Oh, Heung-Kwon; Yu, Sung A; Moon, Sang Hui; Choe, Eun Kyung; Oh, Tae Young; Park, Kyu Joo.
Afiliação
  • Ryoo SB; Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul 110-744, Korea.
  • Oh HK; Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul 110-744, Korea.
  • Yu SA; Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul 110-744, Korea. ; Department of Physiology, Seoul National University College of Medicine, Seoul 110-744, Korea.
  • Moon SH; Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul 110-744, Korea.
  • Choe EK; Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul 110-744, Korea. ; Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul 135-984, Korea.
  • Oh TY; Dong-A, Pharmaceutical Co, Seoul 130-823, Korea.
  • Park KJ; Division of Colorectal Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul 110-744, Korea.
Korean J Physiol Pharmacol ; 18(5): 383-90, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25352757
ABSTRACT
Gastrointestinal motility consists of phasic slow-wave contractions and the migrating motor complex (MMC). Eupatilin (Stillen®) has been widely used to treat gastritis and peptic ulcers, and various cytokines and neuropeptides are thought to be involved, which can affect gastrointestinal motility. We performed a study to identify the effects of eupatilin on lower gastrointestinal motility with electromechanical recordings of smooth muscles in the human ileum and colon. Ileum and colon samples were obtained from patients undergoing bowel resection. The tissues were immediately stored in oxygenated Krebs-Ringer's bicarbonate solution, and conventional microelectrode recordings from muscle cells and tension recordings from muscle strips and ileal or colonic segments were performed. Eupatilin was perfused into the tissue chamber, and changes in membrane potentials and contractions were measured. Hyperpolarization of resting membrane potential (RMP) was observed after administration of eupatilin. The amplitude, AUC, and frequency of tension recordings from circular and longitudinal smooth muscle strips and bowel segments of the ileum and colon were significantly decreased after admission of eupatilin. Eupatilin elicited dose-dependent decreases during segmental tension recordings. In conclusion, eupatilin (Stillen®) showed inhibitory effects on the human ileum and colon. We propose that this drug may be useful for treating diseases that increase bowel motility, but further studies are necessary.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Korean J Physiol Pharmacol Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Korean J Physiol Pharmacol Ano de publicação: 2014 Tipo de documento: Article