Chemistry of lipid A: at the heart of innate immunity.
Chemistry
; 21(2): 500-19, 2015 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-25353096
ABSTRACT
In many Gram-negative bacteria, lipopolysaccharide (LPS) and its lipidâ
A moiety are pivotal for bacterial survival. Depending on its structure, lipidâ
A carries the toxic properties of the LPS and acts as a potent elicitor of the host innate immune system via the Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD-2) receptor complex. It often causes a wide variety of biological effects ranging from a remarkable enhancement of the resistance to the infection to an uncontrolled and massive immune response resulting in sepsis and septic shock. Since the bioactivity of lipidâ
A is strongly influenced by its primary structure, a broad range of chemical syntheses of lipidâ
A derivatives have made an enormous contribution to the characterization of lipidâ
A bioactivity, providing novel pharmacological targets for the development of new biomedical therapies. Here, we describe and discuss the chemical aspects regarding lipidâ
A and its role in innate immunity, from the (bio)synthesis, isolation and characterization to the molecular recognition at the atomic level.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Bactérias Gram-Negativas
/
Bactérias Gram-Negativas
/
Imunidade Inata
/
Lipídeo A
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2015
Tipo de documento:
Article