Coherent feedforward transcriptional regulatory motifs enhance drug resistance.
Phys Rev E Stat Nonlin Soft Matter Phys
; 89(5): 052708, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-25353830
ABSTRACT
Fluctuations in gene expression give identical cells access to a spectrum of phenotypes that can serve as a transient, nongenetic basis for natural selection by temporarily increasing drug resistance. In this study, we demonstrate using mathematical modeling and simulation that certain gene regulatory network motifs, specifically coherent feedforward loop motifs, can facilitate the development of nongenetic resistance by increasing cell-to-cell variability and the time scale at which beneficial phenotypic states can be maintained. Our results highlight how regulatory network motifs enabling transient, nongenetic inheritance play an important role in defining reproductive fitness in adverse environments and provide a selective advantage subject to evolutionary pressure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resistência a Medicamentos
/
Redes Reguladoras de Genes
/
Modelos Biológicos
Idioma:
En
Revista:
Phys Rev E Stat Nonlin Soft Matter Phys
Assunto da revista:
BIOFISICA
/
FISIOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article