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Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990.
McBride, Christopher M; Levine, Barry; Xia, Yi; Bellamacina, Cornelia; Machajewski, Timothy; Gao, Zhenhai; Renhowe, Paul; Antonios-McCrea, William; Barsanti, Paul; Brinner, Kristin; Costales, Abran; Doughan, Brandon; Lin, Xiaodong; Louie, Alicia; McKenna, Maureen; Mendenhall, Kris; Poon, Daniel; Rico, Alice; Wang, Michael; Williams, Teresa E; Abrams, Tinya; Fong, Susan; Hendrickson, Thomas; Lei, Dachuan; Lin, Julie; Menezes, Daniel; Pryer, Nancy; Taverna, Pietro; Xu, Yongjin; Zhou, Yasheen; Shafer, Cynthia M.
Afiliação
  • McBride CM; Global Discovery Chemistry/Oncology & Exploratory Chemistry, Novartis Institutes for Biomedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
J Med Chem ; 57(21): 9124-9, 2014 Nov 13.
Article em En | MEDLINE | ID: mdl-25368984
Utilizing structure-based drug design, a novel dihydropyridopyrimidinone series which exhibited potent Hsp90 inhibition, good pharmacokinetics upon oral administration, and an excellent pharmacokinetic/pharmacodynamic relationship in vivo was developed from a commercial hit. The exploration of this series led to the selection of NVP-HSP990 as a development candidate.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridonas / Pirimidinas / Antineoplásicos Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridonas / Pirimidinas / Antineoplásicos Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos