TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-&#954;B.

Wi, Sae Mi; Moon, Gyuyoung; Kim, Juhong; Kim, Seong-Tae; Shim, Jae-Hyuck; Chun, Eunyoung; Lee, Ki-Young

TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB.

Wi, Sae Mi; Moon, Gyuyoung; Kim, Juhong; Kim, Seong-Tae; Shim, Jae-Hyuck; Chun, Eunyoung; Lee, Ki-Young.

Afiliação

Wi SM; From the Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.
Moon G; From the Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.
Kim J; From the Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.
Kim ST; From the Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.
Shim JH; the Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York 10065.
Chun E; the Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115 echun@hsph.harvard.edu.
Lee KY; From the Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea, thylee@skku.edu.

J Biol Chem ; 289(51): 35205-14, 2014 Dec 19.

Article em En | MEDLINE | ID: mdl-25371197

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; MAP Quinase Quinase Quinases/metabolismo; NF-kappa B/metabolismo; Fator 6 Associado a Receptor de TNF/metabolismo; Receptor 4 Toll-Like/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/genética; Western Blotting; Linhagem Celular Tumoral; Perfilação da Expressão Gênica; Células HEK293; Humanos; Lipopolissacarídeos/farmacologia; MAP Quinase Quinase Quinases/genética; Complexos Multiproteicos/metabolismo; Mutação; NF-kappa B/genética; Análise de Sequência com Séries de Oligonucleotídeos; Ligação Proteica/efeitos dos fármacos; Interferência de RNA; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Transdução de Sinais/efeitos dos fármacos; Fator 6 Associado a Receptor de TNF/genética; Receptor 4 Toll-Like/genética

Palavras-chave

Cytokine; ECSIT; Inflammation; Innate Immunity; NF-kappaB; Signal Transduction; TNF Receptor-associated Factor 6; Toll-like Receptors; Transforming Growth Factor-ß-activated Kinase 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / MAP Quinase Quinase Quinases / Proteínas Adaptadoras de Transdução de Sinal / Fator 6 Associado a Receptor de TNF / Receptor 4 Toll-Like Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article

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