Design and biological evaluation of new platinum(II) complexes bearing ligands with DNA-targeting ability.
Inorg Chem
; 53(23): 12627-34, 2014 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-25402634
ABSTRACT
A novel series of platinum(II) complexes bearing aliphatic amines and ligands with DNA-targeting properties was synthesized to achieve more potent and selective metallodrugs. We developed six new platinum-based drugs, which contain methylamine, 1a-c, and isopropylamine, 2a-c, both in the trans position to a selected targeting ligand naphthalimide. The activity of the complexes has been evaluated in order to confirm the improvements from our proposed approach, and the complexes demonstrate better cytotoxic activity on cancer cell lines when compared with the ligands and, importantly, with cisplatin. Further studies were performed to assess their subcellular localization and binding mode to DNA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Compostos de Platina
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Inorg Chem
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Espanha