Synthesis of nitroaromatic compounds as potential anticancer agents.
Anticancer Agents Med Chem
; 15(2): 206-16, 2015.
Article
em En
| MEDLINE
| ID: mdl-25403167
ABSTRACT
Twenty-seven nitrated and non-nitrated compounds have been synthesized and tested for their growth inhibitory activity on three human cancer cells lines. Fourteen compounds were able to inhibit more than 50% of the growth of at least one of the cancer cell lines and five compounds exhibited high antiproliferative activity on human cancer cell lines (IC50 < 8.5 µM). The cytotoxicity of the compounds on Vero cell line was established in vitro to evaluate the selectivity. All active compounds have a good leaving group (bromide or chloride) at the benzylic position, indicating that the mechanism of action of these compounds is related to their alkylating properties. Two compounds (3 and 24) were selected for further studies in mice with Ehrlich solid tumors and display significant antitumor effects in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Antineoplásicos
/
Nitrocompostos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Anticancer Agents Med Chem
Assunto da revista:
ANTINEOPLASICOS
/
QUIMICA
Ano de publicação:
2015
Tipo de documento:
Article