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Combined inhibition of PI3Kß and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive.
Perino, Alessia; Beretta, Martina; Kilic, Ana; Ghigo, Alessandra; Carnevale, Daniela; Repetto, Ivan Enrico; Braccini, Laura; Longo, Dario; Liebig-Gonglach, Michaela; Zaglia, Tania; Iacobucci, Roberta; Mongillo, Marco; Wetzker, Reinhard; Bauer, Michael; Aime, Silvio; Vercelli, Alessandro; Lembo, Giuseppe; Pfeifer, Alexander; Hirsch, Emilio.
Afiliação
  • Perino A; Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy. alessia.perino@epfl.ch alexander.pfeifer@uni-bonn.de emilio.hirsch@unito.it.
  • Beretta M; Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy. Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, D-07747 Jena, Germany.
  • Kilic A; Institute of Pharmacology and Toxicology, University of Bonn, 53127 Bonn, Germany.
  • Ghigo A; Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.
  • Carnevale D; Department of Molecular Medicine, "Sapienza" University of Rome, 00161 Rome, Italy. Department of Angiocardioneurology and Translational Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, 86077 Pozzilli (IS), Italy.
  • Repetto IE; Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience, University of Turin, 10043 Turin, Italy.
  • Braccini L; Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.
  • Longo D; Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.
  • Liebig-Gonglach M; Institute of Pharmacology and Toxicology, University of Bonn, 53127 Bonn, Germany.
  • Zaglia T; Venetian Institute of Molecular Medicine, University of Padova, 35129 Padova, Italy.
  • Iacobucci R; Department of Angiocardioneurology and Translational Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, 86077 Pozzilli (IS), Italy.
  • Mongillo M; Department of Biomedical Sciences and Venetian Institute of Molecular Medicine, University of Padova, 35121 Padova, Italy.
  • Wetzker R; Department of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, 07745 Jena, Germany.
  • Bauer M; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, D-07747 Jena, Germany.
  • Aime S; Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.
  • Vercelli A; Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience, University of Turin, 10043 Turin, Italy.
  • Lembo G; Department of Molecular Medicine, "Sapienza" University of Rome, 00161 Rome, Italy. Department of Angiocardioneurology and Translational Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, 86077 Pozzilli (IS), Italy.
  • Pfeifer A; Institute of Pharmacology and Toxicology, University of Bonn, 53127 Bonn, Germany. alessia.perino@epfl.ch alexander.pfeifer@uni-bonn.de emilio.hirsch@unito.it.
  • Hirsch E; Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy. alessia.perino@epfl.ch alexander.pfeifer@uni-bonn.de emilio.hirsch@unito.it.
Sci Signal ; 7(352): ra110, 2014 Nov 18.
Article em En | MEDLINE | ID: mdl-25406378
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Nervoso Simpático / Alfa-MSH / Tecido Adiposo / Metabolismo Energético / Inibidores de Fosfoinositídeo-3 Quinase / Obesidade Limite: Animals Idioma: En Revista: Sci Signal Assunto da revista: CIENCIA / FISIOLOGIA Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Nervoso Simpático / Alfa-MSH / Tecido Adiposo / Metabolismo Energético / Inibidores de Fosfoinositídeo-3 Quinase / Obesidade Limite: Animals Idioma: En Revista: Sci Signal Assunto da revista: CIENCIA / FISIOLOGIA Ano de publicação: 2014 Tipo de documento: Article