The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling.
Apoptosis
; 20(2): 174-95, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25420757
ABSTRACT
CARD subfamily is the second largest subfamily in the DD superfamily that plays important roles in regulating various signaling pathways, including but not limited to NF-kB activation signaling, apoptosis signaling and inflammatory signaling. The CARD subfamily contains 33 human CARD-containing proteins, regulating the assembly of many signaling complexes, including apoptosome, inflammsome, nodosome, the CBM complex, PIDDosome, the TRAF2 complex, and the MAVS signalosome, by homotypic CARD-CARD interactions. The mechanism of how CARDs find the right binding partner to form a specific complex remains unclear. This review uses different classification schemes to update the classification of CARD-containing proteins. Combining the classification based on domain structures, functions, associated signaling complexes, and roles would help better understand the structural and function diversity of CARD-containing proteins. This review also summarizes recent structural studies on CARDs. Especially, the CARD-containing complexes can be divided into the homodimeric, heterodimeric, oligomeric, filamentous CARD complexes and the CARD-ubiquitin complex. This review will give an overview of the versatile roles of CARDs in regulating signaling transduction, as well as the therapeutic drugs targeting CARD-containing proteins.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
NF-kappa B
/
Apoptose
/
Proteínas Adaptadoras de Sinalização CARD
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Apoptosis
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Taiwan