Magnetic particle imaging with tailored iron oxide nanoparticle tracers.
IEEE Trans Med Imaging
; 34(5): 1077-84, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25438306
ABSTRACT
Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2(∗) -weighted imaging that are sub-optimal for MPI. Here, we describe new tracers tailored to MPI's unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3 × greater signal-to-noise ratio and better spatial resolution than existing commercial tracers in MPI images of phantoms.
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Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Meios de Contraste
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Nanopartículas de Magnetita
Idioma:
En
Revista:
IEEE Trans Med Imaging
Ano de publicação:
2015
Tipo de documento:
Article