Impact of structural differences in hyperbranched polyglycerolpolyethylene glycol nanoparticles on dermal drug delivery and biocompatibility.
Eur J Pharm Biopharm
; 88(3): 625-34, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25445303
ABSTRACT
Polyglycerol scaffolds and nanoparticles emerged as prominent material for various biomedical applications including topical drug delivery. The impact of slight structural modifications on the nanoparticles' properties, drug delivery potential, and biocompatibility, however, is still not fully understood.Hence, we explored the influence of structural modifications of five structurally related polyglycerol-based nanoparticles (PG-PEG, SK1-SK5) on dermal drug delivery efficiency and biocompatibility. The PG-PEG particles were synthesized via randomly and controlled alkylated chemo-enzymatic approaches resulting in significantly varying particle sizes and interactions with guest molecules. Furthermore, weobserved considerably improved dermal drug delivery with the smallest particles SK4 and SK5 (11 nm and 14 nm) which also correlated with well-defined surface properties achieved by the controlled alkylated synthesis approach. The consistently good biocompatibility for all PG-PEG particles was mainly attributed to the neutral surface charge. No irritation potential, major cytotoxicity or genotoxicity was observed. Nevertheless, slightly better biocompatibility was again seen for the particles characterized by alkyl chain substitution in the core and not on the particle surface.Despite the high structural similarity of the PG-PEG particles, the synthesis and the functionalization significantly influenced particle properties, biocompatibility, and most significantly the drug delivery efficiency.
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Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
/
Pele
/
Materiais Biocompatíveis
/
Portadores de Fármacos
/
Preparações Farmacêuticas
/
Nanopartículas
/
Glicerol
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Eur J Pharm Biopharm
Assunto da revista:
FARMACIA
/
FARMACOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article