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DNA methylation dynamics of a maternally methylated DMR in the mouse Dlk1-Dio3 domain.
Zeng, Tie-Bo; He, Hong-Juan; Han, Zheng-Bin; Zhang, Feng-Wei; Huang, Zhi-Jun; Liu, Qi; Cui, Wei; Wu, Qiong.
Afiliação
  • Zeng TB; School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China.
  • He HJ; School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China.
  • Han ZB; School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China.
  • Zhang FW; School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China.
  • Huang ZJ; School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China.
  • Liu Q; School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China.
  • Cui W; School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China.
  • Wu Q; School of Life Science and Technology, State Key Laboratory of Urban Water Resources and Environment, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China. Electronic address: kigo@hit.edu.cn.
FEBS Lett ; 588(24): 4665-71, 2014 Dec 20.
Article em En | MEDLINE | ID: mdl-25447521
ABSTRACT
The mouse delta-like homolog 1 and type III iodothyronine deiodinase (Dlk1-Dio3) imprinted domain contains three known paternally methylated differentially methylated regions (DMRs) intergenic DMR (IG-DMR), maternally expressed 3-DMR (Gtl2-DMR), and Dlk1-DMR. Here, we report the first maternally methylated DMR, CpG island 2 (CGI-2), is located approximately 800 bp downstream of miR-1188. CGI-2 is highly methylated in sperm and oocytes, de-methylated in pre-implantation embryos, and differentially re-methylated during post-implantation development. CGI-2, similarly to Gtl2-DMR and Dlk1-DMR, acquires differential methylation prior to embryonic day 7.5 (E7.5). Both H3K4me3 and H3K9me3 histone modifications are enriched at CGI-2. Furthermore, CCCTC-binding factor (CTCF) binds to both alleles of CGI-2 in vivo. These results contribute to the investigation of imprinting regulation in this domain.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Impressão Genômica / Metilação de DNA / Peptídeos e Proteínas de Sinalização Intercelular / Iodeto Peroxidase / Mães Limite: Animals / Pregnancy Idioma: En Revista: FEBS Lett Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Impressão Genômica / Metilação de DNA / Peptídeos e Proteínas de Sinalização Intercelular / Iodeto Peroxidase / Mães Limite: Animals / Pregnancy Idioma: En Revista: FEBS Lett Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China