Opioids stimulate growth hormone (GH) release in man independently of GH-releasing hormone.
J Clin Endocrinol Metab
; 69(2): 356-8, 1989 Aug.
Article
em En
| MEDLINE
| ID: mdl-2546963
ABSTRACT
The Met-enkephalin analog DAMME [D-Ala2,MePhe4-Met-enkephalin-(o)-o1, FK 33-824] can stimulate GH secretion in man. In this study we investigated the effects of the guanyl derivative of DAMME (G-DAMME) on the serum GH response to an analog of GHRH in normal men. GHRH-(1-29)NH2 and G-DAMME each induced a rise in serum GH, and the increase was greater when both were given together. Since the GHRH-(1-29)NH2 dose (100 micrograms) used was a maximally stimulatory one, these results suggest that the enhancing effect of G-DAMME on GHRH-induced GH release may be mediated through inhibition of somatostatin release.
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Base de dados:
MEDLINE
Assunto principal:
D-Ala(2),MePhe(4),Met(0)-ol-encefalina
/
Hormônio do Crescimento
/
Hormônio Liberador de Hormônio do Crescimento
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Itália