Effects of leukocyte-derived oxidants on sarcolemmal Na,K,ATP-ase and calcium transport.
Adv Exp Med Biol
; 248: 621-8, 1989.
Article
em En
| MEDLINE
| ID: mdl-2551139
ABSTRACT
Our study demonstrated that the Na,K,ATPase activity and ouabain binding sites were reduced by oxidants. Sarcolemmal calcium transport was also inhibited by hydrogen peroxide and HOC1. The action of HOC1 on the sarcolemmal functions was 2-3 orders of magnitude more powerful than that of hydrogen peroxide. Effects of hydrogen peroxide consisted of two components, i.e., the first, highly sensitive one, most probably mediated by Fe-catalyzed, site-specific free radical formation, and the second, less potent action by (high concentrations of) hydrogen peroxide. Finally, very low concentrations of hydrogen peroxide potentiated Na,K,ATPase activities when assayed using myocytes.
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Base de dados:
MEDLINE
Assunto principal:
Sarcolema
/
Cálcio
/
Ácido Hipocloroso
/
ATPase Trocadora de Sódio-Potássio
/
Peróxido de Hidrogênio
/
Leucócitos
/
Malonatos
/
Malondialdeído
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Canadá