Meroterpenes with toll-like receptor 3 regulating activity from the endophytic fungus Guignardia mangiferae.
Planta Med
; 81(2): 145-51, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25519918
ABSTRACT
The endophytic fungus Guignardia mangiferae isolated from Ilex cornuta leaves was shown to produce a family of meroterpenes with toll-like receptor 3 regulating activity (1-9), of which 1-3 possessed new structures. The absolute stereochemistry of 1-3 was assigned through a combination of nuclear magnetic resonance experiments, chemical derivation, CD spectra, and single-crystal X-ray diffraction analyses (CuK α ). The precursor labeled cultivation suggests that these meroterpenes are most likely assembled through terpenoid-shikimate pathways. Moreover, meroterpenes 1-3, 5-7, and 9 selectively upregulate, but 4 and 8 downregulate the toll-like receptor 3 expression in mouse dendritic cells at 10.0 µM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Terpenos
/
Ilex
/
Receptor 3 Toll-Like
Idioma:
En
Revista:
Planta Med
Ano de publicação:
2015
Tipo de documento:
Article