Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice.

Taylor, Samuel J; Thien, Christine B F; Dagger, Samantha A; Duyvestyn, Johanna M; Grove, Carolyn S; Lee, Benjamin H; Gilliland, D Gary; Langdon, Wallace Y

Taylor, Samuel J; Thien, Christine B F; Dagger, Samantha A; Duyvestyn, Johanna M; Grove, Carolyn S; Lee, Benjamin H; Gilliland, D Gary; Langdon, Wallace Y.

Afiliação

Taylor SJ; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia.
Thien CB; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia.
Dagger SA; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia.
Duyvestyn JM; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia.
Grove CS; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia; PathWest Division of Clinical Pathology, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia.
Lee BH; Novartis Institute for Biomedical Research, Cambridge, MA, USA.
Gilliland DG; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Langdon WY; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia. Electronic address: wally.langdon@uwa.edu.au.

Exp Hematol ; 43(3): 191-206.e1, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25534201

Assuntos

Leucemia Mieloide/enzimologia; Leucemia Mieloide/genética; Proteínas Proto-Oncogênicas c-cbl/genética; Tirosina Quinase 3 Semelhante a fms/genética; Animais; Regulação Neoplásica da Expressão Gênica; Predisposição Genética para Doença; Immunoblotting; Imuno-Histoquímica; Leucemia Mieloide/fisiopatologia; Camundongos; Mutação; Domínios RING Finger/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide / Proteínas Proto-Oncogênicas c-cbl / Tirosina Quinase 3 Semelhante a fms Limite: Animals Idioma: En Revista: Exp Hematol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália

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