Methylmercury impairs canonical dopamine metabolism in rat undifferentiated pheochromocytoma (PC12) cells by indirect inhibition of aldehyde dehydrogenase.

Tiernan, Chelsea T; Edwin, Ethan A; Hawong, Hae-Young; Ríos-Cabanillas, Mónica; Goudreau, John L; Atchison, William D; Lookingland, Keith J

Tiernan, Chelsea T; Edwin, Ethan A; Hawong, Hae-Young; Ríos-Cabanillas, Mónica; Goudreau, John L; Atchison, William D; Lookingland, Keith J.

Afiliação

Tiernan CT; *Neuroscience Program, Department of Pharmacology and Toxicology, Department of Biochemistry and Molecular Biology, College of Osteopathic Medicine and Department of Neurology and Ophthalmology, Michigan State University, East Lansing, Michigan 48824 tiernan8@msu.edu.
Edwin EA; *Neuroscience Program, Department of Pharmacology and Toxicology, Department of Biochemistry and Molecular Biology, College of Osteopathic Medicine and Department of Neurology and Ophthalmology, Michigan State University, East Lansing, Michigan 48824.
Hawong HY; *Neuroscience Program, Department of Pharmacology and Toxicology, Department of Biochemistry and Molecular Biology, College of Osteopathic Medicine and Department of Neurology and Ophthalmology, Michigan State University, East Lansing, Michigan 48824 *Neuroscience Program, Department of Pharmacology
Ríos-Cabanillas M; *Neuroscience Program, Department of Pharmacology and Toxicology, Department of Biochemistry and Molecular Biology, College of Osteopathic Medicine and Department of Neurology and Ophthalmology, Michigan State University, East Lansing, Michigan 48824.
Goudreau JL; *Neuroscience Program, Department of Pharmacology and Toxicology, Department of Biochemistry and Molecular Biology, College of Osteopathic Medicine and Department of Neurology and Ophthalmology, Michigan State University, East Lansing, Michigan 48824 *Neuroscience Program, Department of Pharmacology
Atchison WD; *Neuroscience Program, Department of Pharmacology and Toxicology, Department of Biochemistry and Molecular Biology, College of Osteopathic Medicine and Department of Neurology and Ophthalmology, Michigan State University, East Lansing, Michigan 48824 *Neuroscience Program, Department of Pharmacology
Lookingland KJ; *Neuroscience Program, Department of Pharmacology and Toxicology, Department of Biochemistry and Molecular Biology, College of Osteopathic Medicine and Department of Neurology and Ophthalmology, Michigan State University, East Lansing, Michigan 48824 *Neuroscience Program, Department of Pharmacology

Toxicol Sci ; 144(2): 347-56, 2015 Apr.

Article em En | MEDLINE | ID: mdl-25601988

Assuntos

Aldeído Desidrogenase/antagonistas & inibidores; Dopamina/metabolismo; Compostos de Metilmercúrio/toxicidade; Feocromocitoma/metabolismo; Aldeído Desidrogenase/metabolismo; Animais; Isoflavonas/farmacologia; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/fisiologia; NAD/metabolismo; Células PC12; Feocromocitoma/enzimologia; Feocromocitoma/patologia; Ratos; Rotenona/farmacologia

Palavras-chave

PC12 cell; aldehyde dehydrogenase; dopamine metabolism; methylmercury-induced neurotoxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Feocromocitoma / Dopamina / Aldeído Desidrogenase / Compostos de Metilmercúrio Limite: Animals Idioma: En Revista: Toxicol Sci Assunto da revista: TOXICOLOGIA Ano de publicação: 2015 Tipo de documento: Article

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