Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover.
Aging Cell
; 14(2): 219-27, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25627171
ABSTRACT
In healthy humans, lymphocyte populations are maintained at a relatively constant size throughout life, reflecting a balance between lymphocyte production and loss. Given the profound immunological changes that occur during healthy aging, including a significant decline in T-cell production by the thymus, lymphocyte maintenance in the elderly is generally thought to require homeostatic alterations in lymphocyte dynamics. Surprisingly, using in vivo (2) H2 O labeling, we find similar dynamics of most lymphocyte subsets between young adult and elderly healthy individuals. As the contribution of thymic output to T-cell production is only minor from young adulthood onward, compensatory increases in peripheral T-cell division rates are not required to maintain the T-cell pool, despite a tenfold decline in thymic output. These fundamental insights will aid the interpretation of further research into aging and clinical conditions related to disturbed lymphocyte dynamics.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Linfócitos T
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Aging Cell
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Holanda