Prasugrel inhibits platelet-enhanced pro-inflammatory CD4+ T cell responses in humans.
Atherosclerosis
; 239(1): 283-6, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25635327
ABSTRACT
While platelets have well characterized effects on monocytes, the effect of platelet activation on CD4+ T-cell differentiation and cytokine production is not clear. To examine the effects of platelet T-cell interactions on T-cell phenotype, and whether these interactions were altered by prasugrel, we conducted a randomized, double-blind, placebo-controlled crossover study in healthy subjects. At baseline the addition of platelets to CD4+ T-cells resulted in an increase in the release of pro-inflammatory cytokine IFN-γ (192% increase in IFN-γ levels, p = 0.01) and pro-inflammatory CD4+ phenotypes, (38% and 58% increase in Th1 and Th17 phenotypic markers respectively, p = 0.01) but no change in Tregs. Prasugrel abolished the effects of platelets on CD4+ T-cells with similar levels of pro-inflammatory cytokines and cell numbers to T-cells stimulated. Antiplatelet therapy may provide therapeutic benefit both from direct platelet inhibition and also through indirect effects on immune response development.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
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Linfócitos T CD4-Positivos
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Cloridrato de Prasugrel
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Inflamação
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adult
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Humans
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Middle aged
Idioma:
En
Revista:
Atherosclerosis
Ano de publicação:
2015
Tipo de documento:
Article