Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage.
Aging Cell
; 14(2): 162-9, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25645366
ABSTRACT
Lamins A/C have been implicated in DNA damage response pathways. We show that the DNA repair protein 53BP1 is a lamin A/C binding protein. In undamaged human dermal fibroblasts (HDF), 53BP1 is a nucleoskeleton protein. 53BP1 binds to lamins A/C via its Tudor domain, and this is abrogated by DNA damage. Lamins A/C regulate 53BP1 levels and consequently lamin A/C-null HDF display a 53BP1 null-like phenotype. Our data favour a model in which lamins A/C maintain a nucleoplasmic pool of 53BP1 in order to facilitate its rapid recruitment to sites of DNA damage and could explain why an absence of lamin A/C accelerates aging.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Lamina Tipo A
/
Peptídeos e Proteínas de Sinalização Intracelular
Limite:
Humans
Idioma:
En
Revista:
Aging Cell
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Dinamarca