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Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.
Peck, Kayla M; Cockrell, Adam S; Yount, Boyd L; Scobey, Trevor; Baric, Ralph S; Heise, Mark T.
Afiliação
  • Peck KM; Department of Biology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
  • Cockrell AS; Genetics, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
  • Yount BL; Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
  • Scobey T; Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
  • Baric RS; Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA Microbiology and Immunology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA rbaric@unc.edu mark_heisem@med.unc.edu.
  • Heise MT; Genetics, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA Microbiology and Immunology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA rbaric@unc.edu mark_heisem@med.unc.edu.
J Virol ; 89(8): 4696-9, 2015 Apr.
Article em En | MEDLINE | ID: mdl-25653445
ABSTRACT
Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity. Position 330 changes the charge and glycosylation state of mDPP4. We show that glycosylation is a major factor impacting DPP4 receptor function. These results provide insight into DPP4 species-specific differences impacting MERS-CoV host range and may inform MERS-CoV mouse model development.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Modelos Moleculares / Infecções por Coronavirus / Dipeptidil Peptidase 4 / Internalização do Vírus / Coronavírus da Síndrome Respiratória do Oriente Médio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Virol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Modelos Moleculares / Infecções por Coronavirus / Dipeptidil Peptidase 4 / Internalização do Vírus / Coronavírus da Síndrome Respiratória do Oriente Médio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Virol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos