The price they paid.

ABSTRACT

BACKGROUND: Several individuals integral to the development of evidence-based medicine endured hardship for their efforts and beliefs. CASE PRESENTATION We present the history of three individuals who were integral to the formation of evidence-based medicine. All three individuals suffered as a result of resistance to change from colleagues as well as from within the profession. CONCLUSION: Individual and professional collegiality in the face of change should be maintained. The efforts of our predecessors are honored and provide us with inspiration.