Classification of group B streptococci with reduced ß-lactam susceptibility (GBS-RBS) based on the amino acid substitutions in PBPs.
J Antimicrob Chemother
; 70(6): 1601-3, 2015.
Article
em En
| MEDLINE
| ID: mdl-25667406
ABSTRACT
All clinical isolates of group B Streptococcus (GBS; Streptococcus agalactiae) are considered uniformly susceptible to ß-lactams, including penicillins. However, GBS with reduced penicillin susceptibility (PRGBS) were first identified by our group in Japan and have also been reported from North America. PRGBS are non-susceptible to penicillin because of acquisition of amino acid substitutions near the conserved active-site motifs in PBP2X. In particular, V405A and Q557E are considered the key amino acid substitutions responsible for penicillin non-susceptibility. We revealed that in addition to the substitutions in PBP2X, an amino acid substitution in PBP1A confers high-level cephalosporin resistance in GBS. As the number of publications on GBS with reduced ß-lactam susceptibility (GBS-RBS), especially PRGBS, and concomitantly the need for a systematic classification of GBS-RBS is increasing, we propose here a classification of GBS-RBS based on the amino acid substitutions in their PBPs.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptococcus agalactiae
/
Substituição de Aminoácidos
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Farmacorresistência Bacteriana
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Beta-Lactamas
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Proteínas de Ligação às Penicilinas
Limite:
Humans
País/Região como assunto:
America do norte
/
Asia
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Japão