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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory.
Li, P; Rial, D; Canas, P M; Yoo, J-H; Li, W; Zhou, X; Wang, Y; van Westen, G J P; Payen, M-P; Augusto, E; Gonçalves, N; Tomé, A R; Li, Z; Wu, Z; Hou, X; Zhou, Y; IJzerman, A P; PIJzerman, Ad; Boyden, E S; Cunha, R A; Qu, J; Chen, J-F.
Afiliação
  • Li P; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
  • Rial D; Molecular Biology Center, State Key Laboratory of Trauma, Burn, and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China.
  • Canas PM; CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
  • Yoo JH; CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
  • Li W; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
  • Zhou X; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
  • Wang Y; Molecular Biology Center, State Key Laboratory of Trauma, Burn, and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China.
  • van Westen GJ; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College Wenzhou, Zhejiang, China.
  • Payen MP; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
  • Augusto E; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Gonçalves N; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
  • Tomé AR; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
  • Li Z; CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
  • Wu Z; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
  • Hou X; CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
  • Zhou Y; CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
  • IJzerman AP; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College Wenzhou, Zhejiang, China.
  • PIJzerman A; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College Wenzhou, Zhejiang, China.
  • Boyden ES; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
  • Cunha RA; Molecular Biology Center, State Key Laboratory of Trauma, Burn, and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China.
  • Chen JF; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Mol Psychiatry ; 20(11): 1339-49, 2015 Nov.
Article em En | MEDLINE | ID: mdl-25687775
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico / Receptores A2 de Adenosina / Hipocampo / Transtornos da Memória Limite: Animals / Humans Idioma: En Revista: Mol Psychiatry Assunto da revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico / Receptores A2 de Adenosina / Hipocampo / Transtornos da Memória Limite: Animals / Humans Idioma: En Revista: Mol Psychiatry Assunto da revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos