A role for actin polymerization in persistent pulmonary hypertension of the newborn.
Can J Physiol Pharmacol
; 93(3): 185-94, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25695400
ABSTRACT
Persistent pulmonary hypertension of the newborn (PPHN) is defined as the failure of normal pulmonary vascular relaxation at birth. Hypoxia is known to impede postnatal disassembly of the actin cytoskeleton in pulmonary arterial myocytes, resulting in elevation of smooth muscle α-actin and γ-actin content in elastic and resistance pulmonary arteries in PPHN compared with age-matched controls. This review examines the original histological characterization of PPHN with attention to cytoskeletal structural remodeling and actin isoform abundance, reviews the existing evidence for understanding the biophysical and biochemical forces at play during neonatal circulatory transition, and specifically addresses the role of the cortical actin architecture, primarily identified as γ-actin, in the transduction of mechanical force in the hypoxic PPHN pulmonary circuit.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Actinas
/
Multimerização Proteica
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Hipertensão Pulmonar
Limite:
Animals
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Humans
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Newborn
Idioma:
En
Revista:
Can J Physiol Pharmacol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Canadá