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Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.
Walter, Dagmar; Lier, Amelie; Geiselhart, Anja; Thalheimer, Frederic B; Huntscha, Sina; Sobotta, Mirko C; Moehrle, Bettina; Brocks, David; Bayindir, Irem; Kaschutnig, Paul; Muedder, Katja; Klein, Corinna; Jauch, Anna; Schroeder, Timm; Geiger, Hartmut; Dick, Tobias P; Holland-Letz, Tim; Schmezer, Peter; Lane, Steven W; Rieger, Michael A; Essers, Marieke A G; Williams, David A; Trumpp, Andreas; Milsom, Michael D.
Afiliação
  • Walter D; Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany.
  • Lier A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany.
  • Geiselhart A; Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, Experimental Hematology Group, 69120 Heidelberg, Germany.
  • Thalheimer FB; LOEWE Center for Cell and Gene Therapy and Department of Hematology/Oncology, Goethe University Frankfurt, 60595 Frankfurt am Main, Germany.
  • Huntscha S; Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany.
  • Sobotta MC; Deutsches Krebsforschungszentrum (DKFZ), DKFZ-ZMBH Alliance, Division of Redox Regulation, 69120 Heidelberg, Germany.
  • Moehrle B; Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, 89081 Ulm, Germany.
  • Brocks D; Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, Experimental Hematology Group, 69120 Heidelberg, Germany.
  • Bayindir I; Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, Experimental Hematology Group, 69120 Heidelberg, Germany.
  • Kaschutnig P; Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, Experimental Hematology Group, 69120 Heidelberg, Germany.
  • Muedder K; Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, 69120 Heidelberg, Germany.
  • Klein C; Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany.
  • Jauch A; Institute of Human Genetics, University of Heidelberg, 69120 Heidelberg, Germany.
  • Schroeder T; ETH Zurich, Department of Biosystems Science and Engineering, 4058 Basel, Switzerland.
  • Geiger H; 1] Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, 89081 Ulm, Germany [2] Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
  • Dick TP; Deutsches Krebsforschungszentrum (DKFZ), DKFZ-ZMBH Alliance, Division of Redox Regulation, 69120 Heidelberg, Germany.
  • Holland-Letz T; Deutsches Krebsforschungszentrum (DKFZ), Division of Biostatistics, 69120 Heidelberg, Germany.
  • Schmezer P; Deutsches Krebsforschungszentrum (DKFZ), Division of Epigenomics and Cancer Risk Factors, 69120 Heidelberg, Germany.
  • Lane SW; QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane 4006, Australia.
  • Rieger MA; LOEWE Center for Cell and Gene Therapy and Department of Hematology/Oncology, Goethe University Frankfurt, 60595 Frankfurt am Main, Germany.
  • Essers MA; 1] Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany [2] Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, Hematopoietic Stem Cells and Stress Group, 69120 Heidelberg, Germany.
  • Williams DA; 1] Boston Children's Hospital, Boston, Massachusetts 02115, USA [2] Dana-Faber Cancer Institute, Boston, Massachusetts 02115, USA [3] Harvard Stem Cell Institute, Boston, Massachusetts 02138, USA [4] Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Trumpp A; 1] Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany [2] Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, 69120 Heidelberg, Germany.
  • Milsom MD; 1] Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany [2] Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, Experimental Hematology Group, 69120 Heidelberg, Germany.
Nature ; 520(7548): 549-52, 2015 Apr 23.
Article em En | MEDLINE | ID: mdl-25707806
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Células-Tronco Hematopoéticas / Ciclo Celular Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Células-Tronco Hematopoéticas / Ciclo Celular Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha