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Transmembrane protein 173 inhibits RANKL-induced osteoclast differentiation.
Choe, Chung-Hyeon; Park, In Sun; Park, Jisang; Yu, Kang-Yeol; Jang, Hyonseok; Kim, Ju; Jang, Yong-Suk.
Afiliação
  • Choe CH; Jeonju Biomaterials Institute, Jeonju 561-360, Republic of Korea; Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju 561-756, Republic of Korea.
  • Park IS; Jeonju Biomaterials Institute, Jeonju 561-360, Republic of Korea.
  • Park J; Department of Bioactive Material Sciences and Research Center of Bioactive Materials, Chonbuk National University, Jeonju 561-756, Republic of Korea.
  • Yu KY; Jeonju Biomaterials Institute, Jeonju 561-360, Republic of Korea.
  • Jang H; Department of Oral and Maxillofacial Surgery, Korea University Ansan Hospital, Ansan 425-707, Republic of Korea.
  • Kim J; Jeonju Biomaterials Institute, Jeonju 561-360, Republic of Korea. Electronic address: ju226@jbmi.re.kr.
  • Jang YS; Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju 561-756, Republic of Korea; Department of Bioactive Material Sciences and Research Center of Bioactive Materials, Chonbuk National University, Jeonju 561-756, Republic of Korea.
FEBS Lett ; 589(7): 836-41, 2015 Mar 24.
Article em En | MEDLINE | ID: mdl-25728277
Tmem173 was identified as a growth inhibitor associated with major histocompatibility complex (MHC) class II and a potential stimulator for IFN-ß, an innate immune inducer and a negative feedback controller for RANKL-induced osteoclast differentiation of monocytic macrophage cells. In this study, we confirmed that transmembrane protein 173 (Tmem173) overexpression inhibited the expression of osteoclast-specific genes, tartrate-resistant acid phosphatase (TRAP), cathepsin K, and matrix metalloproteinase-9 (MMP-9), as well as bone resorption pit formation in RANKL-treated RAW 264.7 cells. Activation of osteoclast-specific transcription factors, c-Fos and nuclear factor of activated T cells cytoplasmic-1 (NFATc1), and RANKL-induced activation of ERK were also down-regulated by Tmem173 overexpression. Collectively, these results suggest that Tmem173 plays a regulatory role in RANKL-RANK-mediated signaling in osteoclastogenesis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoclastos / Ligante RANK / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: FEBS Lett Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoclastos / Ligante RANK / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: FEBS Lett Ano de publicação: 2015 Tipo de documento: Article