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TRAIL and Bortezomib: killing cancer with two stones.
Qureshi, Muhammad Zahid; Romero, Mirna Azalea; Attar, Rukset; Javed, Zeeshan; Farooqi, Ammad Ahmad.
Afiliação
  • Qureshi MZ; Department of Chemistry, GCU Lahore, Lahore, Pakistan E-mail : ammadahmad638@yahoo.com.
Asian Pac J Cancer Prev ; 16(4): 1671-4, 2015.
Article em En | MEDLINE | ID: mdl-25743849
Cancer genomics and proteomics have undergone considerable broadening in the past decades and increasingly it is being realized that solid/liquid phase microarrays and high-throughput resequencing have provided platforms to improve our existing knowledge of determinants of cancer development, progression and survival. Loss of apoptosis is a widely and deeply studied process and different approaches are being used to restore apoptosis in resistant cancer phenotype. Modulating the balance between pro-apoptotic and anti-apoptotic proteins is essential to induce apoptosis. It is becoming more understood that pharmacological inhibition of the proteasome might prove to be an effective option in improving TRAIL induced apoptosis in cancer cells. Keeping in view rapidly accumulating evidence of carcinogenesis, metastasis, resistance against wide ranging therapeutics and loss of apoptosis, better knowledge regarding tumor suppressors, oncogenes, pro-apoptotic and anti-apotptic proteins will be helpful in translating the findings from benchtop to bedside.
Assuntos
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Base de dados: MEDLINE Assunto principal: Apoptose / Complexo de Endopeptidases do Proteassoma / Proteínas Reguladoras de Apoptose / Ligante Indutor de Apoptose Relacionado a TNF / Bortezomib / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Revista: Asian Pac J Cancer Prev Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Apoptose / Complexo de Endopeptidases do Proteassoma / Proteínas Reguladoras de Apoptose / Ligante Indutor de Apoptose Relacionado a TNF / Bortezomib / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Revista: Asian Pac J Cancer Prev Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article