Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota.
Nat Commun
; 6: 6495, 2015 Mar 11.
Article
em En
| MEDLINE
| ID: mdl-25757720
ABSTRACT
Obesity is a pandemic disease associated with many metabolic alterations and involves several organs and systems. The endocannabinoid system (ECS) appears to be a key regulator of energy homeostasis and metabolism. Here we show that specific deletion of the ECS synthesizing enzyme, NAPE-PLD, in adipocytes induces obesity, glucose intolerance, adipose tissue inflammation and altered lipid metabolism. We report that Napepld-deleted mice present an altered browning programme and are less responsive to cold-induced browning, highlighting the essential role of NAPE-PLD in regulating energy homeostasis and metabolism in the physiological state. Our results indicate that these alterations are mediated by a shift in gut microbiota composition that can partially transfer the phenotype to germ-free mice. Together, our findings uncover a role of adipose tissue NAPE-PLD on whole-body metabolism and provide support for targeting NAPE-PLD-derived bioactive lipids to treat obesity and related metabolic disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfolipase D
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Tecido Adiposo Marrom
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Intolerância à Glucose
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Microbioma Gastrointestinal
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Obesidade
Limite:
Animals
Idioma:
En
Revista:
Nat Commun
Assunto da revista:
BIOLOGIA
/
CIENCIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Bélgica