Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice.

Huang, LinZhang; Fan, BaoYan; Ma, Ang; Shaul, Philip W; Zhu, HaiBo

Huang, LinZhang; Fan, BaoYan; Ma, Ang; Shaul, Philip W; Zhu, HaiBo.

Afiliação

Huang L; State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Fan B; State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ma A; State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Shaul PW; Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Zhu H; State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

J Lipid Res ; 56(5): 986-97, 2015 May.

Article em En | MEDLINE | ID: mdl-25761370

Assuntos

Transportador 1 de Cassete de Ligação de ATP/metabolismo; Adenosina/análogos & derivados; Aterosclerose/tratamento farmacológico; HDL-Colesterol/metabolismo; Transportador 1 de Cassete de Ligação de ATP/genética; Adenosina/farmacologia; Animais; Aterosclerose/metabolismo; Linhagem Celular; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Camundongos Endogâmicos C57BL; Camundongos Knockout; Transporte Proteico/efeitos dos fármacos; Proteólise; RNA Mensageiro/genética; RNA Mensageiro/metabolismo

Palavras-chave

ATP binding cassette transporter A1; high density lipoprotein; macrophage; reverse cholesterol transport

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenosina / Aterosclerose / Transportador 1 de Cassete de Ligação de ATP / HDL-Colesterol Limite: Animals Idioma: En Revista: J Lipid Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China

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