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Receptor usage and cell entry of porcine epidemic diarrhea coronavirus.
Liu, Chang; Tang, Jian; Ma, Yuanmei; Liang, Xueya; Yang, Yang; Peng, Guiqing; Qi, Qianqian; Jiang, Shibo; Li, Jianrong; Du, Lanying; Li, Fang.
Afiliação
  • Liu C; Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
  • Tang J; Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.
  • Ma Y; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
  • Liang X; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
  • Yang Y; Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
  • Peng G; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.
  • Qi Q; Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China.
  • Jiang S; Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China.
  • Li J; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
  • Du L; Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA ldu@nybloodcenter.org lifang@umn.edu.
  • Li F; Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA ldu@nybloodcenter.org lifang@umn.edu.
J Virol ; 89(11): 6121-5, 2015 Jun.
Article em En | MEDLINE | ID: mdl-25787280
Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Virais / Antígenos CD13 / Ácido N-Acetilneuramínico / Vírus da Diarreia Epidêmica Suína / Ligação Viral / Internalização do Vírus Limite: Animals / Humans Idioma: En Revista: J Virol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Virais / Antígenos CD13 / Ácido N-Acetilneuramínico / Vírus da Diarreia Epidêmica Suína / Ligação Viral / Internalização do Vírus Limite: Animals / Humans Idioma: En Revista: J Virol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos