Blood-brain barrier permeability of gefitinib in patients with brain metastases from non-small-cell lung cancer before and during whole brain radiation therapy.

Zeng, Yin-Duo; Liao, Hai; Qin, Tao; Zhang, Li; Wei, Wei-Dong; Liang, Jian-Zhong; Xu, Fei; Dinglin, Xiao-Xiao; Ma, Shu-Xiang; Chen, Li-Kun

Zeng, Yin-Duo; Liao, Hai; Qin, Tao; Zhang, Li; Wei, Wei-Dong; Liang, Jian-Zhong; Xu, Fei; Dinglin, Xiao-Xiao; Ma, Shu-Xiang; Chen, Li-Kun.

Afiliação

Zeng YD; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Liao H; Lab of Phase I Clinical Study, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Qin T; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Zhang L; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Wei WD; Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Liang JZ; Department of Pathology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Xu F; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Dinglin XX; Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
Ma SX; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Chen LK; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.

Oncotarget ; 6(10): 8366-76, 2015 Apr 10.

Article em En | MEDLINE | ID: mdl-25788260

Assuntos

Barreira Hematoencefálica/metabolismo; Neoplasias Encefálicas/radioterapia; Neoplasias Encefálicas/secundário; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/metabolismo; Quinazolinas/farmacocinética; Adulto; Idoso; Antineoplásicos/farmacocinética; Antineoplásicos/uso terapêutico; Barreira Hematoencefálica/patologia; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/metabolismo; Carcinoma Pulmonar de Células não Pequenas/patologia; Feminino; Gefitinibe; Humanos; Neoplasias Pulmonares/patologia; Masculino; Pessoa de Meia-Idade; Metástase Neoplásica; Prognóstico; Quinazolinas/uso terapêutico; Adulto Jovem

Palavras-chave

blood-brain barrier; brain metastasis; gefitinib; non-small-cell lung cancer; whole brain radiation therapy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Neoplasias Encefálicas / Barreira Hematoencefálica / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China

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