Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGFR: transcriptional profiling and molecular docking study for kidney cancer therapeutics.

Mirza, Zeenat; Schulten, Hans-Juergen; Farsi, Hasan Ma; Al-Maghrabi, Jaudah A; Gari, Mamdooh A; Chaudhary, Adeel Ga; Abuzenadah, Adel M; Al-Qahtani, Mohammed H; Karim, Sajjad

Mirza, Zeenat; Schulten, Hans-Juergen; Farsi, Hasan Ma; Al-Maghrabi, Jaudah A; Gari, Mamdooh A; Chaudhary, Adeel Ga; Abuzenadah, Adel M; Al-Qahtani, Mohammed H; Karim, Sajjad.

Afiliação

Mirza Z; King Fahd Medical Research Center, King Abdulaziz University, PO BOX 80216, Jeddah, 21589, Saudi Arabia.
Schulten HJ; Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical Sciences, King Abdulaziz University, PO BOX 80216, Jeddah, 21589, Saudi Arabia.
Farsi HM; Department of Urology, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Al-Maghrabi JA; Department of Pathology, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; Department of Pathology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Gari MA; Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical Sciences, King Abdulaziz University, PO BOX 80216, Jeddah, 21589, Saudi Arabia.
Chaudhary AG; King Fahd Medical Research Center, King Abdulaziz University, PO BOX 80216, Jeddah, 21589, Saudi Arabia; Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical Sciences, King Abdulaziz University, PO BOX 80216, Jeddah, 21589, Saudi Arabia.
Abuzenadah AM; King Fahd Medical Research Center, King Abdulaziz University, PO BOX 80216, Jeddah, 21589, Saudi Arabia; Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical Sciences, King Abdulaziz University, PO BOX 80216, Jeddah, 21589, Saudi Arabia; KACST Technology Innovation Center in
Al-Qahtani MH; Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical Sciences, King Abdulaziz University, PO BOX 80216, Jeddah, 21589, Saudi Arabia.
Karim S; Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical Sciences, King Abdulaziz University, PO BOX 80216, Jeddah, 21589, Saudi Arabia.

PLoS One ; 10(3): e0119765, 2015.

Article em En | MEDLINE | ID: mdl-25789858

Assuntos

Calgranulina A/biossíntese; Receptores ErbB/biossíntese; Neoplasias Renais/tratamento farmacológico; Estaurosporina/análogos & derivados; Calgranulina A/química; Calgranulina A/genética; Proliferação de Células/efeitos dos fármacos; Descoberta de Drogas; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Receptores ErbB/química; Receptores ErbB/genética; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Neoplasias Renais/genética; Neoplasias Renais/patologia; Masculino; Pessoa de Meia-Idade; Simulação de Acoplamento Molecular; Terapia de Alvo Molecular; Conformação Proteica/efeitos dos fármacos; Inibidores de Proteínas Quinases/administração & dosagem; Transdução de Sinais/efeitos dos fármacos; Estaurosporina/administração & dosagem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estaurosporina / Calgranulina A / Receptores ErbB / Neoplasias Renais Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Arábia Saudita

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