IRE1&#945;-TRAF2-ASK1 complex-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to CXC195-induced apoptosis in human bladder carcinoma T24 cells.

Zeng, Tao; Peng, Lifen; Chao, Haichao; Xi, Haibo; Fu, Bin; Wang, Yibing; Zhu, Zunwei; Wang, Gongxian

IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to CXC195-induced apoptosis in human bladder carcinoma T24 cells.

Zeng, Tao; Peng, Lifen; Chao, Haichao; Xi, Haibo; Fu, Bin; Wang, Yibing; Zhu, Zunwei; Wang, Gongxian.

Afiliação

Zeng T; School of Medicine, Nanchang University, Nanchang, Jiangxi, PR China. Electronic address: zengtaonanchang@163.com.
Peng L; E.N.T. Department, The People's Hospital of Jiangxi Province, Nanchang, PR China.
Chao H; School of Medicine, Nanchang University, Nanchang, Jiangxi, PR China.
Xi H; Institute of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, PR China.
Fu B; Institute of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, PR China.
Wang Y; Institute of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, PR China.
Zhu Z; Department of Urology, The People's Hospital of Jiangxi Province, Nanchang, PR China.
Wang G; Institute of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, PR China.

Biochem Biophys Res Commun ; 460(3): 530-6, 2015 May 08.

Article em En | MEDLINE | ID: mdl-25797626

Assuntos

Retículo Endoplasmático/metabolismo; Endorribonucleases/metabolismo; MAP Quinase Quinase Quinase 5/metabolismo; Mitocôndrias/fisiologia; Piperazinas/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Pirazinas/metabolismo; Fator 2 Associado a Receptor de TNF/metabolismo; Neoplasias da Bexiga Urinária/patologia; Apoptose; Linhagem Celular Tumoral; Chaperona BiP do Retículo Endoplasmático; Endorribonucleases/genética; Técnicas de Silenciamento de Genes; Humanos; Estresse Oxidativo; Proteínas Serina-Treonina Quinases/genética; Neoplasias da Bexiga Urinária/metabolismo

Palavras-chave

Apoptosis; Bladder urothelial carcinoma; CXC195; ER stress; IRE1a-TRAF2-ASK1 complex; JNK

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Pirazinas / Neoplasias da Bexiga Urinária / Proteínas Serina-Treonina Quinases / MAP Quinase Quinase Quinase 5 / Fator 2 Associado a Receptor de TNF / Retículo Endoplasmático / Endorribonucleases / Mitocôndrias Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2015 Tipo de documento: Article

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