Proton-Pump Inhibitor Exposure Aggravates Clostridium difficile-Associated Colitis: Evidence From a Mouse Model.

Hung, Yuan-Pin; Ko, Wen-Chien; Chou, Po-Han; Chen, Yi-Hsuan; Lin, Hsiao-Ju; Liu, Ya-Hui; Tsai, Hung-Wen; Lee, Jen-Chieh; Tsai, Pei-Jane

Hung, Yuan-Pin; Ko, Wen-Chien; Chou, Po-Han; Chen, Yi-Hsuan; Lin, Hsiao-Ju; Liu, Ya-Hui; Tsai, Hung-Wen; Lee, Jen-Chieh; Tsai, Pei-Jane.

Afiliação

Hung YP; Department of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare Department of Internal Medicine Graduate Institute of Clinical Medicine, National Health Research Institutes, Tainan, Taiwan.
Ko WC; Department of Internal Medicine Center for Infection Control, National Cheng Kung University Hospital Department of Medicine, National Cheng Kung University Medical College.
Chou PH; Department of Medical Laboratory Science and Biotechnology.
Chen YH; Department of Medical Laboratory Science and Biotechnology.
Lin HJ; Department of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare Department of Internal Medicine Graduate Institute of Clinical Medicine, National Health Research Institutes, Tainan, Taiwan.
Liu YH; Department of Medical Laboratory Science and Biotechnology.
Tsai HW; Department of Pathology.
Lee JC; Department of Internal Medicine.
Tsai PJ; Department of Medical Laboratory Science and Biotechnology Center of Infectious Disease and Signaling Research, National Cheng Kung University.

J Infect Dis ; 212(4): 654-63, 2015 Aug 15.

Article em En | MEDLINE | ID: mdl-25805751

Assuntos

Clostridioides difficile; Enterocolite Pseudomembranosa/induzido quimicamente; Esomeprazol/efeitos adversos; Inibidores da Bomba de Prótons/efeitos adversos; Animais; Antibacterianos/efeitos adversos; Clostridioides difficile/efeitos dos fármacos; Clostridioides difficile/crescimento & desenvolvimento; Colo/patologia; Citocinas/metabolismo; Modelos Animais de Doenças; Enterocolite Pseudomembranosa/patologia; Fezes/microbiologia; Regulação Bacteriana da Expressão Gênica; Genes Reporter; Células Caliciformes; Camundongos; NF-kappa B/metabolismo; Regulação para Cima

Palavras-chave

C. difficile infection; NF-κB reporter mice; gut barrier permeability; mouse model; proton-pump inhibitor

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Enterocolite Pseudomembranosa / Clostridioides difficile / Inibidores da Bomba de Prótons / Esomeprazol Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Infect Dis Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Taiwan

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google