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Understanding Disease-Drug Interactions in Cancer Patients: Implications for Dosing Within the Therapeutic Window.
Coutant, D E; Kulanthaivel, P; Turner, P K; Bell, R L; Baldwin, J; Wijayawardana, S R; Pitou, C; Hall, S D.
Afiliação
  • Coutant DE; Department of Drug Disposition, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Kulanthaivel P; Department of Drug Disposition, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Turner PK; Pharmacokinetics and Pharmacodynamics, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Bell RL; Pharmacokinetics and Pharmacodynamics, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Baldwin J; Pharmacokinetics and Pharmacodynamics, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Wijayawardana SR; Department of Statistics-Oncology, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Pitou C; Pharmacokinetics and Pharmacodynamics, Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Hall SD; Department of Drug Disposition, Eli Lilly and Company, Indianapolis, Indiana, USA.
Clin Pharmacol Ther ; 98(1): 76-86, 2015 Jul.
Article em En | MEDLINE | ID: mdl-25808023
ABSTRACT
The human inflammatory response can result in the alteration of drug clearance through effects on metabolizing enzymes or transporters. In this article we briefly review the theory of how cancer can lead to indirect changes in drug metabolism, review acute phase proteins and cytokines as markers of changes in cytochrome P450 (CYP) activity in cancer patients, and provide clinical case examples of how the inflammation in advanced cancer patients can lead to altered CYP-mediated drug clearance.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos