Cotrimoxazole prophylaxis and antiretroviral therapy: an observational cohort study in China.
Bull World Health Organ
; 93(3): 152-60, 2015 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-25838611
ABSTRACT
OBJECTIVE:
To assess if cotrimoxazole prophylaxis administered early during antiretroviral therapy (ART) reduces mortality in Chinese adults who are infected with human immunodeficiency virus (HIV).METHODS:
We did a retrospective observational cohort study using data from the Chinese national free antiretroviral database. Patients older than 14 years who started ART between 1 January 2010 and 31 December 2012 and had baseline CD4+ T-lymphocyte (CD4+ cell) count less than 200 cells/µL were followed until death, loss to follow-up or 31 December 2013. Hazard ratios (HRs) for several variables were calculated using multivariate analyses.FINDINGS:
The analysis involved 23 816 HIV-infected patients, 2706 of whom died during the follow-up. Mortality in patients who did and did not start cotrimoxazole during the first 6 months of ART was 5.3 and 7.0 per 100 person-years, respectively. Cotrimoxazole was associated with a 37% reduction in mortality (hazard ratio, HR 0.63; 95% confidence interval, CI 0.56-0.70). Cotrimoxazole in addition to ART reduced mortality significantly over follow-up lasting 6 months (HR 0.65; 95% CI 0.59-0.73), 12 months (HR 0.58; 95% CI 0.49-0.70), 18 months (HR 0.49; 95% CI 0.38-0.63) and 24 months (HR 0.66; 95% CI 0.48-0.90). The mortality reduction was evident in patients with baseline CD4+ cell counts less than 50 cells/µL (HR 0.60; 95% CI 0.54-0.67), 50-99 cells/µL (HR 0.66; 95% CI 0.56-0.78) and 100-199 cells/µL (HR 0.78; 95% CI 0.62-0.98).CONCLUSION:
Cotrimoxazole prophylaxis started early during ART reduced mortality and should be offered to HIV-infected patients in low- and middle-income countries.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Combinação Trimetoprima e Sulfametoxazol
/
Antibioticoprofilaxia
/
Antibacterianos
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Bull World Health Organ
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
China