Your browser doesn't support javascript.
loading
Organ-level quorum sensing directs regeneration in hair stem cell populations.
Chen, Chih-Chiang; Wang, Lei; Plikus, Maksim V; Jiang, Ting Xin; Murray, Philip J; Ramos, Raul; Guerrero-Juarez, Christian F; Hughes, Michael W; Lee, Oscar K; Shi, Songtao; Widelitz, Randall B; Lander, Arthur D; Chuong, Cheng Ming.
Afiliação
  • Chen CC; Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA; Department of Dermatology, Taipei Veterans General Hospital, Taipei 112, Taiwan, ROC; Institute of Clinical Medicine and Department of Dermatology, National Yang-Ming University, Taipei, Taiwan 112, ROC.
  • Wang L; State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
  • Plikus MV; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA.
  • Jiang TX; Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA.
  • Murray PJ; Division of Mathematics, University of Dundee, Dundee DD1 4HN, UK.
  • Ramos R; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA.
  • Guerrero-Juarez CF; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA.
  • Hughes MW; International Laboratory of Wound Repair and Regeneration and Institute of Clinical Medicine, National Cheng Kung University, Tainan 701, Taiwan, ROC.
  • Lee OK; Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei and Center for Stem Cell Research, National Yang-Ming University and Veterans General Hospital, Taipei 112, Taiwan, ROC.
  • Shi S; Department of Anatomy and Cell Biology, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA 19104, USA.
  • Widelitz RB; Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA.
  • Lander AD; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA; Department of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA.
  • Chuong CM; Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA; Institute of Clinical Medicine and Department of Dermatology, National Yang-Ming University, Taipei, Taiwan 112, ROC; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan Universit
Cell ; 161(2): 277-90, 2015 Apr 09.
Article em En | MEDLINE | ID: mdl-25860610
ABSTRACT
Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regeneration of up to five times more neighboring, unplucked resting hairs, indicating activation of a collective decision-making process. Through data modeling, the range of the quorum signal was estimated to be on the order of 1 mm, greater than expected for a diffusible molecular cue. Molecular and genetic analysis uncovered a two-step mechanism, where release of CCL2 from injured hairs leads to recruitment of TNF-α-secreting macrophages, which accumulate and signal to both plucked and unplucked follicles. By coupling immune response with regeneration, this mechanism allows skin to respond predictively to distress, disregarding mild injury, while meeting stronger injury with full-scale cooperative activation of stem cells.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Folículo Piloso Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Folículo Piloso Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2015 Tipo de documento: Article