Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with ß-amyloid anti-aggregation properties and beneficial effects on memory in vivo.

Wieckowska, Anna; Wieckowski, Krzysztof; Bajda, Marek; Brus, Boris; Salat, Kinga; Czerwinska, Paulina; Gobec, Stanislav; Filipek, Barbara; Malawska, Barbara

Wieckowska, Anna; Wieckowski, Krzysztof; Bajda, Marek; Brus, Boris; Salat, Kinga; Czerwinska, Paulina; Gobec, Stanislav; Filipek, Barbara; Malawska, Barbara.

Afiliação

Wieckowska A; Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Medical College, Jagiellonian University, Kraków, Poland.
Wieckowski K; Department of Organic Chemistry, Medical College, Jagiellonian University, Kraków, Poland.
Bajda M; Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Medical College, Jagiellonian University, Kraków, Poland.
Brus B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Salat K; Department of Pharmacodynamics, Medical College, Jagiellonian University, Kraków, Poland.
Czerwinska P; Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Medical College, Jagiellonian University, Kraków, Poland.
Gobec S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Filipek B; Department of Pharmacodynamics, Medical College, Jagiellonian University, Kraków, Poland.
Malawska B; Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry, Medical College, Jagiellonian University, Kraków, Poland. Electronic address: mfmalaws@cyf-kr.edu.pl.

Bioorg Med Chem ; 23(10): 2445-57, 2015 May 15.

Article em En | MEDLINE | ID: mdl-25868744

Assuntos

Acetilcolinesterase/química; Doença de Alzheimer/tratamento farmacológico; Amnésia/tratamento farmacológico; Butirilcolinesterase/química; Inibidores da Colinesterase/síntese química; Fármacos Neuroprotetores/síntese química; Piperidinas/síntese química; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Amnésia/induzido quimicamente; Amnésia/metabolismo; Amnésia/patologia; Peptídeos beta-Amiloides; Animais; Barreira Hematoencefálica/efeitos dos fármacos; Inibidores da Colinesterase/farmacologia; Modelos Animais de Doenças; Donepezila; Humanos; Indanos/farmacologia; Indóis/química; Masculino; Memória/efeitos dos fármacos; Camundongos; Modelos Moleculares; Fármacos Neuroprotetores/farmacologia; Ftalimidas/química; Piperidinas/farmacologia; Agregados Proteicos/efeitos dos fármacos; Escopolamina; Relação Estrutura-Atividade

Palavras-chave

Alzheimer's disease; Bloodbrain barrier permeability; Cholinesterase inhibitors; Indole; N-benzylpiperidine; Passive avoidance; Phthalimide; ß-Amyloid aggregation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Acetilcolinesterase / Butirilcolinesterase / Inibidores da Colinesterase / Fármacos Neuroprotetores / Doença de Alzheimer / Amnésia Limite: Animals / Humans / Male Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Polônia

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