Extracellular MRP8/14 is a regulator of ß2 integrin-dependent neutrophil slow rolling and adhesion.
Nat Commun
; 6: 6915, 2015 Apr 20.
Article
em En
| MEDLINE
| ID: mdl-25892652
Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in the leukocyte adhesion cascade. We show that E-selectin-PSGL-1 interaction during neutrophil rolling triggers Mrp8/14 secretion. Released MRP8/14 in turn activates a TLR4-mediated, Rap1-GTPase-dependent pathway of rapid ß2 integrin activation in neutrophils. This extracellular activation loop reduces leukocyte rolling velocity and stimulates adhesion. Thus, we identify Mrp8/14 and TLR4 as important modulators of the leukocyte recruitment cascade during inflammation in vivo.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adesão Celular
/
Antígenos CD18
/
Calgranulina A
/
Calgranulina B
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Migração e Rolagem de Leucócitos
/
Neutrófilos
Limite:
Animals
Idioma:
En
Revista:
Nat Commun
Assunto da revista:
BIOLOGIA
/
CIENCIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Alemanha