Molybdopterin biosynthesis-Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP.
Biochim Biophys Acta
; 1854(9): 1073-7, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-25896388
ABSTRACT
The first step in the biosynthesis of the molybdopterin cofactor involves an unprecedented insertion of the purine C8 carbon between the C2' and C3' carbons of the ribose moiety of GTP. Here we review mechanistic studies on this remarkable transformation. This article is part of a Special Issue entitled Cofactor-dependent proteins evolution, chemical diversity and bio-applications.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Purinas
/
Ribose
/
Coenzimas
/
Proteínas de Escherichia coli
/
Biocatálise
/
Guanosina Trifosfato
/
Isomerases
/
Metaloproteínas
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos